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Giannopoulou, E.Z. ; Puff, R. ; Beyerlein, A. ; von Luettichau, I.* ; Boerschmann, H.* ; Schatz, D.* ; Atkinson, M.* ; Haller, M.J.* ; Egger, D.* ; Burdach, S.* ; Ziegler, A.-G.

Effect of a single autologous cord blood infusion on beta-cell and immune function in children with new onset type 1 diabetes: A non-randomized, controlled trial.

Pediatr. Diabetes 15, 100-109 (2014)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Background The application of autologous cord blood in children with type 1 diabetes has been found to be safe, but not to preserve beta-cell function in a previous study, which, however, had not included a control group. Objective To compare the changes of metabolic and immune function over time between cord blood infused children and natural controls. Subjects and methods Seven children with newly diagnosed type 1 diabetes underwent a single autologous cord blood infusion and 10 children were enrolled as natural controls in a non-randomized, controlled, open label intervention trial. Primary analyses were performed 1 year following cord blood infusion. Cases and controls were compared regarding metabolic [area under the curve (AUC) and peak C-peptide, insulin use, and HbA1c] and immune outcome (islet autoantibody titer and T-cell response), adjusted for age, gender, diabetes duration, and baseline levels. Results There were no significant adverse events related to the infusion. Metabolic and immune outcomes were not significantly different at 12 months follow-up between infused children and controls (e.g., adjusted p = 0.244 for AUC C-peptide, adjusted p = 0.820 for insulin use, adjusted p = 0.772 for peripheral regulatory T cells). Six-month change of AUC C-peptide correlated significantly with the number of infused CD34+ cells (r = 0.931, p = 0.002). Conclusions An autologous cord blood infusion does not change the natural course of metabolic and immune parameters after disease onset. However, the content of CD34+ cells in the stored blood sample might offer potential for improvement of future cell therapies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Regulatory T-lymphocytes ; C-peptide ; Stem Cells; Antibody Standardization Program; Bone-marrow-transplantation; Cd4(+)cd25(+) T-cells; Suppressor Function; Stem-cells; Autoantibodies; Diseases; Assays; Outcomes
ISSN (print) / ISBN 1399-543X
e-ISSN 1399-5448
Journal Pediatric Diabetes
Quellenangaben Volume: 15, Issue: 2, Pages: 100-109 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place Hoboken
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)