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as soon as is submitted to ZB.
Hybrid fluorescence tomography / X-ray tomography improves reconstruction quality.
In: European Conference on Biomedical Optics 2009 (European Conference on Biomedical Optics, ECBO 2009, 14. - 18. Juni 2009, Munich; Germany). 2009.:7370_0H (Optics InfoBase Conference Papers)
A novel hybrid imaging system for simultaneous X-ray and Fluorescence Tomography is presented, capitalizing on 360°-projection free-space fluorescence tomography. The system is implemented within a commercial micro-CT scanner allowing reconstructions with a resolution of 95μm. Acquired data sets are intrinsically coregistered in the same coordinate system and can be used to correctly localize reconstructed fluorescence distributions with morphological features. More importantly, the micro-CT data, automatically segmented into different organ and tissue segments can be used to guide the fluorescence reconstruction algorithm and reduce the illcoditioning of the inverse problem. We showcase the use of the system and the improvements in image quality for lesions in brain and lung.
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Publication type
Article: Conference contribution
Document type
Scientific Article
ISSN (print) / ISBN
2162-2701
Conference Title
European Conference on Biomedical Optics, ECBO 2009
Conference Date
14. - 18. Juni 2009
Conference Location
Munich; Germany
Proceedings Title
European Conference on Biomedical Optics 2009
Quellenangaben
Article Number: 7370_0H
Series
Optics InfoBase Conference Papers
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Institute(s)
Institute of Biological and Medical Imaging (IBMI)