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Mook-Kanamori, D.O.* ; Selim, M.M.E.* ; Takiddin, A.H.* ; Al-Homsi, H.* ; Al-Mahmoud, K.A.S.* ; Al-Obaidli, A.* ; Zirie, M.A.* ; Rowe, J.* ; Yousri, N.A.* ; Karoly, E.D.* ; Kocher, T.* ; Gherbi, W.S.* ; Chidiac, O.M.* ; Mook-Kanamori, M.J.* ; Kader, S.A.* ; Al Muftah, W.A.* ; McKeon, C.* ; Suhre, K.

1,5-anhydroglucitol in saliva is a noninvasive marker of short-term glycemic control.

J. Clin. Endocrinol. Metab. 99, E479-E483 (2014)
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Context: In most ethnicities at least a quarter of all cases with diabetes is assumed to be undiagnosed. Screening for diabetes using saliva has been suggested as an effective approach to identify affected individuals. Objective: The objective of the study was to identify a noninvasive metabolic marker of type 2 diabetes in saliva. Design and Setting: In a case-control study of type 2 diabetes, we used a clinical metabolomics discovery study to screen for diabetes-relevant metabolic readouts in saliva, using blood and urine as a reference. With a combination of three metabolomics platforms based on nontargeted mass spectrometry, we examined 2178 metabolites in saliva, blood plasma, and urine samples from 188 subjects with type 2 diabetes and 181 controls of Arab and Asian ethnicities. Results: We found a strong association of type 2 diabetes with 1,5-anhydroglucitol (1,5-AG) in saliva (P = 3.6 x 10(-13)). Levels of 1,5-AG in saliva highly correlated with 1,5-AG levels in blood and inversely correlated with blood glucose and glycosylated hemoglobin levels. These findings were robust across three different non-Caucasian ethnicities (Arabs, South Asians, and Filipinos), irrespective of body mass index, age, and gender. Conclusions: Clinical studies have already established 1,5-AG in blood as a reliable marker of short-term glycemic control. Our study suggests that 1,5-AG in saliva can be used in national screening programs for undiagnosed diabetes, which are of particular interest for Middle Eastern countries with young populations and exceptionally high diabetes rates.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Impaired Glucose Regulation ; Diabetes-mellitus ; Systems
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Journal Journal of Clinical Endocrinology & Metabolism, The
Quellenangaben Volume: 99, Issue: 3, Pages: E479-E483 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Bethesda, Md.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Bioinformatics and Systems Biology (IBIS)