Open Access Green as soon as Postprint is submitted to ZB.
Unveiling the molecular mechanisms behind selenium-related diseases through knockout mouse studies.
Antioxid. Redox Signal. 12, 851-865 (2010)
Selenium (Se), in the form of the 21st amino acid selenocysteine, is an integral part of selenoproteins and essential for mammals. While a large number of health claims for Se has been proposed in a diverse set of diseases, little is known about the precise molecular mechanisms and the physiological roles of selenoproteins. With the recent and rigorous application of reverse genetics in the mouse, great strides have been made to address this on a more molecular level. In this review, we focus on results obtained from the application of mouse molecular genetics in mouse physiology and discuss these insights into the physiological actions of selenoproteins in light of evidence from human genetics.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Times Cited
Scopus
Cited By
Cited By
Altmetric
7.581
2.030
23
40
Annotations
Special Publikation
Hide on homepage
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hydroperoxide glutathione-peroxidase; Selenocydteine transfer-RNA; Deficient transgenic mice; Early embryonic lethality; Cancer prevention trail; Whole-body selenium; Selenoprotein-P; Thioredoxin reductase; Targeted disruption; Oxidative stress
Language
english
Publication Year
2010
HGF-reported in Year
2010
ISSN (print) / ISBN
1523-0864
e-ISSN
1557-7716
Journal
Antioxidants & Redox Signaling
Quellenangaben
Volume: 12,
Issue: 7,
Pages: 851-865
Publisher
Mary Ann Liebert
Reviewing status
Peer reviewed
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
Immune Response and Infection
PSP Element(s)
G-501400-003
G-501400-006
G-501400-006
PubMed ID
19803749
Scopus ID
77649267654
Erfassungsdatum
2010-12-16