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van Rijt, S.H. ; Bein, T.* ; Meiners, S.

Medical nanoparticles for next generation drug delivery to the lungs.

Eur. Respir. J. 44, 765-774 (2014)
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Respiratory diseases are an increasing burden for the ageing population. Although our understanding of these diseases has improved significantly over the past decades, diagnostic and therapeutic options for treating lung diseases, such as chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and lung cancer, remain limited. Multidisciplinary approaches that bridge the gap between medicinal and materials sciences will likely contribute to promising new therapeutic and diagnostic solutions. One such multidisciplinary approach is the use of nanoparticles as carriers for the delivery of drugs. The advantages of using nanoparticles to deliver drugs include: increased drug concentration at the disease site; minimised drug degradation and loss; ease of creating inhalable formulations; and the possibility of specific cell targeting. This article gives a brief overview on the emerging field of nanocarriers as drug delivery vehicles for the treatment of lung diseases.
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Publication type Article: Journal article
Document type Review
Keywords Solid Lipid Nanoparticles; Liposomal Dry Powder; Cystic-fibrosis; Targeted Delivery; Gene-therapy; In-vitro; Alveolar Macrophages; Clinical-evaluation; Endothelial-cells; Folate Receptor
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 44, Issue: 3, Pages: 765-774 Article Number: , Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501600-004
PubMed ID 24791828
DOI 10.1183/09031936.00212813
WOS ID WOS:000341339000029
Erfassungsdatum 2014-05-06
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