PuSH - Publication Server of Helmholtz Zentrum München: Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Steib, K. ; Schäffner, I. ; Jagasia, R. ; Ebert, B. ; Lie, D.C.

Mitochondria modify exercise-induced development of stem cell-derived neurons in the adult brain.

J. Neurosci. 34, 6624-6633 (2014)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Neural stem cells in the adult mammalian hippocampus continuously generate new functional neurons, which modify the hippocampal network and significantly contribute to cognitive processes and mood regulation. Here, we show that the development of new neurons from stem cells in adult mice is paralleled by extensive changes to mitochondrial mass, distribution, and shape. Moreover, exercise-a strong modifier of adult hippocampal neurogenesis-accelerates neuronal maturation and induces a profound increase in mitochondrial content and the presence of mitochondria in dendritic segments. Genetic inhibition of the activity of the mitochondrial fission factor dynamin-related protein 1 (Drp1) inhibits neurogenesis under basal and exercise conditions. Conversely, enhanced Drp1 activity furthers exercise-induced acceleration of neuronal maturation. Collectively, these results indicate that adult hippocampal neurogenesis requires adaptation of the mitochondrial compartment and suggest that mitochondria are targets for enhancing neurogenesis-dependent hippocampal plasticity.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Activity ; Adult Hippocampal Neurogenesis ; Exercise ; Mitochondria ; Stem Cells; Newly Generated Neurons; In-vivo; Born Neurons; Pattern Separation; Dentate Gyrus; Neurogenesis; Hippocampus; Maturation; Morphogenesis; Biogenesis

ISSN (print) / ISBN 0270-6474

e-ISSN 1529-2401

Journal Journal of Neuroscience

Quellenangaben Volume: 34, Issue: 19, Pages: 6624-6633

Publisher Society for Neuroscience

Publishing Place Washington

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Developmental Genetics (IDG)