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MALDI mass spectrometry imaging of formalin-fixed paraffin-embedded tissues in clinical research.
Histol. Histopathol. 29, 1365-1376 (2014)
The molecular investigation of archived formalin-fixed, paraffin-embedded (FFPE) tissue samples provides the chance to obtain molecular patterns as indicatives for treatment and clinical end points. MALDI mass spectrometry imaging is capable of localizing molecules like proteins and peptides in tissue sections and became a favorite platform for the targeted and non-targeted approaches, especially in clinical investigations for biomarker research. In FFPE tissues the recovery of proteomic information is constrained by fixation-induced cross-links of proteins. The promising new insights obtained from FFPE in combination with the comprehensive patients' data caused much progress in the optimization of MS imaging protocols to investigate FFPE samples. This review presents the past and current research in MALDI MS imaging of FFPE tissues, demonstrating the improvement of analyses, their actual limitations, but also the promising future perspectives for histopathological and tissue-based research.
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Publication type
Article: Journal article
Document type
Review
Keywords
Ffpe (formalin-fixed, Paraffin-embedded) ; Mass Spectrometry Imaging ; Maldi ; Proteins ; Peptides
ISSN (print) / ISBN
0213-3911
e-ISSN
1699-5848
Journal
Histology and Histopathology
Quellenangaben
Volume: 29,
Issue: 11,
Pages: 1365-1376
Publisher
Jiménez-Godoy, S.A.
Non-patent literature
Publications
Reviewing status
Peer reviewed