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Cabrera, M.C.* ; Tilahun, E.* ; Nakles, R.* ; Diaz-Cruz, E.S.* ; Charabaty, A.* ; Suy, S.* ; Jackson, P.* ; Ley, L.* ; Slack, R.* ; Jha, R.* ; Collins, S.P.* ; Haddad, N.* ; Kallakury, B.V.* ; Schroeder, T. ; Pishvaian, M.J.* ; Furth, P.A.*

Human pancreatic cancer-associated stellate cells remain activated after in vivo chemoradiation.

Front. Oncol. 4:102 (2014)
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Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibrotic reaction or desmoplasia and complex involvement of the surrounding tumor microenvironment. Pancreatic stellate cells are a key mediator of the pancreatic matrix and they promote progression and invasion of pancreatic cancer by increasing cell proliferation and offering protection against therapeutic interventions. Our study utilizes human tumor-derived pancreatic stellate cells (HTPSCs) isolated from fine needle aspirates of pancreatic cancer tissue from patients with locally advanced, unresectable pancreatic adenocarcinoma before and after treatment with full-dose gemcitabine plus concurrent hypo-fractionated stereotactic radiosurgery. We show that HTPSCs survive in vivo chemotherapy and radiotherapy treatment and display a more activated phenotype post-therapy. These data support the idea that stellate cells play an essential role in supporting and promoting pancreatic cancer and further research is needed to develop novel treatments targeting the pancreatic tumor microenvironment.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Pdac ; Chemotherapy ; Gemcitabine ; Pancreatic Cancer ; Radiation ; Stellate Cells
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 2234-943X
e-ISSN 2234-943X
Journal Frontiers in Oncology
Quellenangaben Volume: 4, Issue: , Pages: , Article Number: 102 Supplement: ,
Publisher Frontiers
Reviewing status Peer reviewed
Institute(s) Institute of Stem Cell Research (ISF)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
PubMed ID 24847445
DOI 10.3389/fonc.2014.00102
Scopus ID 84904649320
Erfassungsdatum 2014-05-24
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