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Open Access Green as soon as Postprint is submitted to ZB.
Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis.
Circ. Res. 114, 1772-1787 (2014)
Tertiary lymphoid organs emerge in tissues in response to nonresolving inflammation. Recent research characterized artery tertiary lymphoid organs in the aorta adventitia of aged apolipoprotein E-deficient mice. The atherosclerosis-associated lymphocyte aggregates are organized into distinct compartments, including separate T-cell areas harboring conventional, monocyte-derived, lymphoid, and plasmacytoid dendritic cells, as well as activated T-cell effectors and memory cells; B-cell follicles containing follicular dendritic cells in activated germinal centers; and peripheral niches of plasma cells. Artery tertiary lymphoid organs show marked neoangiogenesis, aberrant lymphangiogenesis, and extensive induction of high endothelial venules. Moreover, newly formed lymph node-like conduits connect the external lamina with high endothelial venules in T-cell areas and also extend into germinal centers. Mouse artery tertiary lymphoid organs recruit large numbers of naïve T cells and harbor lymphocyte subsets with opposing activities, including CD4(+) and CD8(+) effector and memory T cells, natural and induced CD4(+) regulatory T cells, and memory B cells at different stages of differentiation. These data suggest that artery tertiary lymphoid organs participate in primary immune responses and organize T- and B-cell autoimmune responses in advanced atherosclerosis. In this review, we discuss the novel concept that pro- and antiatherogenic immune responses toward unknown arterial wall-derived autoantigens may be organized by artery tertiary lymphoid organs and that disruption of the balance between pro- and antiatherogenic immune cell subsets may trigger clinically overt atherosclerosis.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adventitia ; Aging ; Atherosclerosis ; Autoimmune Response; Porcine Coronary-arteries; Smooth-muscle-cells; Regulatory T-cells; Hev-restricted Sulfotransferase; Progressive Multiple-sclerosis; Obstructive Pulmonary-disease; Driven Clonal Proliferation; Inflammatory-bowel-disease; Lung Allograft Dysfunction; Lymphotoxin-beta-receptor
ISSN (print) / ISBN
0009-7330
e-ISSN
1524-4571
Journal
Circulation Research
Quellenangaben
Volume: 114,
Issue: 11,
Pages: 1772-1787
Publisher
Lippincott Williams & Wilkins
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Molecular Immunology (IMI)