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Brüske, I. ; Thiering, E. ; Heinrich, J. ; Huster, K.M.* ; Nowak, D.*

Respirable quartz dust exposure and airway obstruction: A systematic review and meta-analysis.

Occup. Environ. Med. 71, 583-589 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Studies on exposure to respirable quartz dust at the workplace and the development of chronic obstructive pulmonary disease (COPD) were selected into a systematic review and meta-analysed to obtain an overall estimate of forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) reduction. PubMed and Embase were searched from 1970 to 2010. In total, 257 cross-sectional and longitudinal studies were identified that reported on inorganic dust exposure and had available lung function data. Of the 55 publications which met our inclusion criteria, 11 reported on associations with occupational exposure to respirable quartz dust. The combined average effect estimate of respirable quartz dust on spirometric parameters was obtained using a random effects model meta-analysis. Between-study heterogeneity was assessed via the I(2) statistic. Most studies found a significant negative association of FEV1 and FEV1/FVC related to increasing exposure to crystalline quartz at the workplace. One study found an effect only for smokers, and one did not observe such an effect at all. The meta-analysis of cross-sectional studies showed that the mean ratio FEV1 to FVC was reduced and FEV1 of workers exposed to respirable quartz dust was 4.6% less than predicted compared with workers with no/low exposure. Both results showed a statistically significant difference. Occupational exposure to respirable quartz dust was associated with a statistically significant decrease in FEV1 and FEV1/FVC, revealing airway obstruction consistent with COPD.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Vermont Granite Workers; Nutrition-examination-survey; Pulmonary-function Loss; Lung-function Decline; Occupational Exposures; General-population; Follow-up; Cumulative Exposure; Chronic-bronchitis; National-health
ISSN (print) / ISBN 1351-0711
e-ISSN 1470-7926
Journal Occupational and Environmental Medicine
Quellenangaben Volume: 71, Issue: 8, Pages: 583-589 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)