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Open Access Green as soon as Postprint is submitted to ZB.
Metabolic profiling in diabetes.
J. Endocrinol. 221, R75-R85 (2014)
Metabolic profiling, or metabolomics, has developed into a mature science in recent years. It has major applications in the study of metabolic disorders. This review addresses issues relevant to the choice of the metabolomics platform, study design and data analysis in diabetes research, and presents recent advances using metabolomics in the identification of markers for altered metabolic pathways, biomarker discovery, challenge studies, metabolic markers of drug efficacy and off-target effects. The role of genetic variance and intermediate metabolic phenotypes and its relevance to diabetes research is also addressed.
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Publication type
Article: Journal article
Document type
Review
Keywords
Diabetes ; Glucose Metabolism ; Insulin Resistance ; Lipid ; Metabolism; Multivariate Statistical-analysis; Chain Amino-acids; Insulin-resistance; Mass-spectrometry; Wide Association; Genome-wide; Serum 1,5-anhydroglucitol; Quantitative-analysis; Plasma Metabolomics; Glucose Challenge
ISSN (print) / ISBN
0022-0795
e-ISSN
1479-6805
Journal
Journal of Endocrinology
Quellenangaben
Volume: 221,
Issue: 3,
Pages: R75-R85
Publisher
Society for Endocrinology
Publishing Place
Bristol
Non-patent literature
Publications
Reviewing status
Peer reviewed