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Open Access Green as soon as Postprint is submitted to ZB.
Genetic variation in soluble epoxide hydrolase (EPHX2) is associated with an increased risk of ischemic stroke in white Europeans.
Stroke 39, 1593-1596 (2008)
Genetic variation in the EPHX2 gene region has been reported to influence susceptibility to ischemic stroke in blacks. We assessed the role of this gene region in white Europeans and performed analyses with regard to stroke subtypes. METHODS: Twenty-six single nucleotide polymorphisms in the EPHX2 gene region were genotyped in 601 patients with ischemic stroke and 736 matched controls. Cases were subtyped according to the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification system. Analyses were done on single markers and haplotypes using a sliding-window approach. RESULTS: Three single nucleotide polymorphisms showed associations with an increased risk for ischemic stroke (allelic models; all P
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
stroke; genetics; EPHX2
ISSN (print) / ISBN
0039-2499
e-ISSN
1524-4628
Journal
Stroke
Quellenangaben
Volume: 39,
Issue: 5,
Pages: 1593-1596
Publisher
Lippincott Williams & Wilkins
Non-patent literature
Publications
Reviewing status
Peer reviewed