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Kim, J.G.* ; Suyama, S.* ; Koch, M.* ; Jin, S.* ; Argente-Arizon, P.* ; Argente, J.* ; Liu, Z.W.* ; Zimmer, M.R.* ; Jeong, J.K.* ; Szigeti-Buck, K.* ; Gao, Y. ; García-Cáceres, C. ; Yi, C.-X. ; Salmaso, N.* ; Vaccarino, F.M.* ; Chowen, J.* ; Diano, S.* ; Dietrich, M.O.* ; Tschöp, M.H. ; Horvath, T.L.*

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.

Nat. Neurosci. 17, 908-910 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Arcuate Nucleus; Pomc Neurons; Obesity; Receptors; Glutamate
ISSN (print) / ISBN 1097-6256
e-ISSN 1546-1726
Journal Nature Neuroscience
Quellenangaben Volume: 17, Issue: 7, Pages: 908-910 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)