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Open Access Green as soon as Postprint is submitted to ZB.
Genetic risk models in age-related macular degeneration.
Adv. Exp. Med. Biol. 801, 291-300 (2014)
Late-stage age-related macular degeneration (AMD) is a common sight-threatening disease of the central retina affecting approximately 1 in 30 Caucasians. Besides age and smoking, common genetic variants from at least 19 gene loci have reproducibly been associated with AMD likely explaining a large proportion of disease. Based on the current knowledge, several models were calculated to predict disease risk each with its own strength and weakness. Here, we review and compare published genetic risk models for AMD with or without additionally accounting for non-genetic factors.
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Publication type
Article: Journal article
Document type
Scientific Article
Editors
Ash, J.D.* ; Grimm, C.* ; Hollyfield, J.G.* ; Anderson, R.E.* ; LaVail, M.M.* ; Bowes Rickman, C.*
Keywords
Age-related macular degeneration ; Susceptibility ; Logistic regression ; Cox regression ; Genetic risk score; Clinical-trial; United-states; Prevalence; Cfh; Progression; Severity; C2
ISSN (print) / ISBN
0065-2598
ISBN
978-1-4614-3208-1
Conference Title
Retinal Degenerative Diseases : Mechanisms and Experimental Therapy
Quellenangaben
Volume: 801,
Pages: 291-300
Series
Retinal Degenerative Diseases
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Genetic Epidemiology (IGE)