PuSH - Publication Server of Helmholtz Zentrum München: The neuroprotective potential of retinal Müller glial cells.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Hauck, S.M. ; von Toerne, C. ; Ueffing, M.

The neuroprotective potential of retinal Müller glial cells.

Adv. Exp. Med. Biol. 801, 381-387 (2014)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Retinal Müller glial cells (RMG) are recognized as essential players providing neurotrophic, metabolic and structural support for retinal neurons as well as mediating inflammatory responses in the retina. While some key neuroprotective molecules in the context of retinal degeneration, such as FGF2, LIF, PEDF have been demonstrated to be of RMG origin, there is yet no comprehensive understanding on the multifaceted role of RMG in orchestrating diverse intercellular functions. In order to systematically as well as functionally analyse RMG reactivity to retinal degeneration and thus explore the RMG-derived signalling molecules in depth, we combined genomics and proteomics approaches based on profiling primary RMGs from mouse and pig. However, since modulations in cell to cell communication by secretion of molecules may not necessarily present with changes in the mRNA profile, we developed shotgun proteomics approaches enabling direct protein profiling of the RMG lysates and secretomes using label-free and SILAC quantitations. We have identified a pool of novel proteins relevant for pro-survival effects transmitted from RMG to retinal neurons and functionally valdidated selected molecules. Additionally, our approach allows to identify RMG reactions to intrinsic and extrinsic stimuli and thus enables to molecularly dissect RMG reactivity relevant for retinal health and disease.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

1.825

0.581