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Enamel matrix derivative in propylene glycol alginate for treatment of infrabony defects with or without systemic doxycycline: 12- and 24-month results.
J. Periodontol. 85, 669-675 (2014)
Background: This aim of this study is to compare regenerative therapy of infrabony defects with and without administration of post-surgical systemic doxycycline (DOXY) 12 and 24 months after therapy. Methods: In each of 57 patients, one infrabony defect (depth >= 4 mm) was treated regeneratively using enamel matrix derivative at two centers (Frankfurt am Main and Heidelberg). By random assignment, patients received either 200 mg DOXY per day or placebo (PLAC) for 7 days after surgery. Twelve and 24 months after surgery, clinical parameters (probing depths [PDs] and vertical clinical attachment level [CAL-V]) and standardized radiographs were obtained. Missing data were managed according to the last observation carried forward. Results: Data of 57 patients (DOXY: 28; PLAC: 29) were analyzed (26 males and 31 females; mean age: 52 +/- 10.2 years; 13 smokers). In both groups, significant (P < 0.01) PD reduction (DOXY: 3.7 +/- 2.2 mm; PLAC: 3.4 +/- 1.7 mm), CAL-V gain (DOXY: 2.7 +/- 1.9 mm; PLAC: 3.0 +/- 1.9 mm), and bone fill (DOXY: 1.6 +/- 2.7 mm; PLAC: 1.8 +/- 3.0 mm) were observed 24 months after surgery. However, the differences between both groups failed to be statistically significant (PD: P = 0.574; CAL-V: P = 0.696; bone fill: P = 0.318). Conclusions: Systemic DOXY, 200 mg/day for 7 days, after regenerative therapy of infrabony defects did not result in better PD reduction, CAL-V gain, or radiographic bone fill compared with PLAC 12 and 24 months after surgery, which may be attributable to low power and, thus, random chance.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Alveolar Bone Loss ; Dental Enamel Proteins ; Doxycycline ; Guided Tissue Regeneration ; Periodontal ; Periodontal Diseases ; Wound Healing; Guided Tissue Regeneration; Controlled Clinical-trial; Deep Intrabony Defects; Periodontal Defects; Bioabsorbable Barriers; Bony Defects; Osseous Defects; Access Flap; Multicenter; Proteins
ISSN (print) / ISBN
0022-3492
e-ISSN
1943-3670
Journal
Journal of Periodontology
Quellenangaben
Volume: 85,
Issue: 5,
Pages: 669-675
Publisher
American Academy of Periodontology
Publishing Place
Chicago
Non-patent literature
Publications
Reviewing status
Peer reviewed