PuSH - Publication Server of Helmholtz Zentrum München: Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Multhoff, G. ; Radons, J.R.* ; Vaupel, P.W.*

Critical role of aberrant angiogenesis in the development of tumor hypoxia and associated radioresistance.

Cancers 6, 813-823 (2014)

Publ. Version/Full Text Volltext

DOI

	Open Access Gold

Abstract
Metrics
Extra information

Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Hypoxia Modifiers ; Hypoxia-inducible Factor (hif) ; Radioresistance ; Tumor Angiogenesis ; Tumor Hypoxia ; Tumor Microcirculation

ISSN (print) / ISBN 2072-6694

Journal Cancers

Quellenangaben Volume: 6, Issue: 2, Pages: 813-823

Publisher MDPI

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Biological and Medical Imaging (IBMI)