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Response to comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".

Science 344:1237 (2014)
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Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
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Publication type Article: Journal article
Document type Letter to the Editor
Keywords Infection; Cells; Mice
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 0036-8075
e-ISSN 1095-9203
Journal Science
Quellenangaben Volume: 344, Issue: 6189, Pages: , Article Number: 1237 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington
Reviewing status Peer reviewed
POF-Topic(s) 30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-502700-003
G-551600-001
PubMed ID 24926011
Erfassungsdatum 2014-06-15