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Response to comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA".
Science 344:1237 (2014)
Publ. Version/Full Text
DOI
PMC
Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.
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Publication type
Article: Journal article
Document type
Letter to the Editor
Keywords
Infection; Cells; Mice
ISSN (print) / ISBN
0036-8075
e-ISSN
1095-9203
Journal
Science
Quellenangaben
Volume: 344,
Issue: 6189,
Article Number: 1237
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
Washington
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)