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Adult neurogenesis in non-mammalian vertebrates.
Bioessays 29, 745-757 (2007)
Adult neurogenesis is an exciting and rapidly advancing field of research. It addresses basic biological questions, such as the how and why of de novo neuronal production during adulthood, as well as medically relevant issues, including the potential link between adult neural stem cells and psychiatric disorders, or how stem cell manipulation might be used as a strategy for neuronal replacement. Current research mainly focuses on rodents, but we review here recent examination of non-mammalian vertebrates, which demonstrates that bona fide adult neural stem cells exist in these species. Importantly, especially in teleost fish, these cells can be abundant and located in various brain areas. Hence, non-mammalian vertebrate species provide invaluable comparative material for extracting core mechanisms of adult neural stem cell maintenance and fate.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Journal
BioEssays
Quellenangaben
Volume: 29,
Issue: 8,
Pages: 745-757
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed