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Lutzweiler, C. ; Meier, R.* ; Rummeny, E.* ; Ntziachristos, V. ; Razansky, D.

Real-time optoacoustic tomography of indocyanine green perfusion in human vasculature.

Opt. Lett. 39, 4061-4064 (2014)

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We interrogated whether optoacoustic tomography could be employed to study blood flow kinetics and bio-distribution of injected fluorescent agents in humans. Using a 128-channel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger, before and after the administration of Indocyanine Green (ICG). We demonstrate that multi-spectral optoacoustic tomography (MSOT) can sense fast flow kinetics and resolve spatio-temporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer.

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