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Open Access Green as soon as Postprint is submitted to ZB.
Real-time optoacoustic tomography of indocyanine green perfusion in human vasculature.
Opt. Lett. 39, 4061-4064 (2014)
We interrogated whether optoacoustic tomography could be employed to study blood flow kinetics and bio-distribution of injected fluorescent agents in humans. Using a 128-channel scanner at a frame rate of 10 images per second, we obtained cross-sectional images of the human finger, before and after the administration of Indocyanine Green (ICG). We demonstrate that multi-spectral optoacoustic tomography (MSOT) can sense fast flow kinetics and resolve spatio-temporal characteristics of a common fluorochrome in human vasculature at clinically relevant concentrations. We further register ICG images with oxygen saturation maps and anatomical views of the proximal interphalangeal joint of a healthy volunteer.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Photoacoustic Tomography; Synovitis; Breast
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Journal
Optics Letters
Quellenangaben
Volume: 39,
Issue: 14,
Pages: 4061-4064
Publisher
Optical Society of America (OSA)
Publishing Place
Washington
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)