Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
Open Access Green as soon as Postprint is submitted to ZB.
Impaired NK cells and increased T regulatory cell numbers during cytotoxic maintenance therapy in AML.
Leuk. Res. 38, 964-969 (2014)
Cyclic cytotoxic maintenance therapy can be applied to patients with AML in post-remission. We studied the immune status of AML patients in complete remission and the effect of maintenance therapy on different immune cell populations. Patients in complete remission had reduced NK, TH and Treg counts and a reduced NK activation capacity. In the course of cytotoxic maintenance therapy, NK counts further declined, while TH and Treg cells increased, with lower proliferative potential of TH cells. We conclude that immunotherapeutic approaches in post-remission have to consider reduced NK cell function and further impairment of cellular immune responses during cytotoxic therapy.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acute Myeloid Leukemia ; Cytotoxic Therapy ; Immunomonitoring ; Maintenance Therapy ; Nk Cell ; T Regulatory Cell
ISSN (print) / ISBN
0145-2126
e-ISSN
1873-5835
Journal
Leukemia Research
Quellenangaben
Volume: 38,
Issue: 8,
Pages: 964-969
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CCG Hematopoetic Cell Transplants (IMI-KHZ)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)