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Open Access Green as soon as Postprint is submitted to ZB.
Kill and spread the word: Stimulation of antitumor immune responses in the context of radiotherapy.
Immunotherapy 6, 597-610 (2014)
Besides the direct, targeted effects of ionizing irradiation (x-ray) on cancer cells, namely DNA damage and cell death induction, indirect, nontargeted ones exist, which are mediated in large part by the immune system. Immunogenic forms of tumor cell death induced by x-ray, including immune modulating danger signals like the heat shock protein 70, adenosine triphosphate, and high-mobility group box 1 protein are presented. Further, antitumor effects exerted by cells of the innate (natural killer cells) as well as adaptive immune system (T cells activated by dendritic cells) are outlined. Tumor cell death inhibiting molecules such as survivin are introduced as suitable target for molecularly tailored therapies in combination with x-ray. Finally, reasonable combinations of immune therapies with radiotherapy are discussed.
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Publication type
Article: Journal article
Document type
Review
Keywords
Abscopal Effect ; Annexin A5 ; Dendritic Cell ; Heat Shock Protein 70 ; High-mobility Group Box Protein 1 ; Immunogenic Tumor Cell Death ; Immunotherapy ; Radiotherapy ; Survivin ; Vaccination; Universal Tumor-antigen; Heat-shock Proteins; Dendritic Cell Vaccination; Local Radiation-therapy; Phase-ii Trial; Cancer-patients; Natural-killer; Breast-cancer; Peptide Vaccination; T-cells
ISSN (print) / ISBN
1750-743X
e-ISSN
1750-7448
Journal
Immunotherapy
Quellenangaben
Volume: 6,
Issue: 5,
Pages: 597-610
Publisher
Future Medicine
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)