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Müllner, M. ; Schlattl, H. ; Oeh, U. ; Hoeschen, C. ; Dietrich, O.*

Feasibility study of spectral Computed Tomography (CT) with gold as a new contrast agent.

Proc. SPIE 9033:90334A (2014)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
Newly developed spectral CTs with a photon-counting and energy-selective detector provide the possibility to obtain additional information about an objectas absorption properties, the footprint of which can be found in the energy spectrum of the detected photons. These new CT systems are capable of yielding valuable insight into the elemental composition of the tissue and open up the way for new CT contrast agents by detecting element-specific K-edge patterns. Gold could be a promising new CT contrast agent. The major goal of this study is to determine the minimum amount of gold that is needed to use it as a spectral CT contrast agent for medical imaging in humans. To reach this goal, Monte Carlo simulations with EGSnrc were performed. The energy-selective detector, on which this study is based, has 6 energy bins and the energy thresholds can be selected freely. First different energy thresholds were analyzed to determine the best energy thresholds with respect to detecting gold. The K-edge imaging algorithm was then applied to the simulation results with these energy bins. The reconstructed images were evaluated with respect to signal-To-noise ratio, contrast-To-noise ratio and contrast. The K-edge imaging algorithm is able to convert the information in the six energy bins into three images, which correspond to the photoelectric effect, Compton scattering and gold content; however, it requires very long computing time. The simulations indicate that at least 0.2w% of gold are required to use it as a CT contrast agent in humans.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Contrast Agent ; Gold ; K-edge Imaging ; Monte Carlo Simulation ; Spectral Ct
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Conference Title Medical Imaging 2014: Physics of Medical Imaging
Conference Date 17-20 February 2014
Conference Location San Diego, CA
Journal Proceedings of SPIE
Quellenangaben Volume: 9033, Issue: , Pages: , Article Number: 90334A Supplement: ,
Publisher SPIE
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Medical Radiation Physics and Diagnostics (AMSD)