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Müller, B.H.* ; Hoeschen, C. ; Grüner, F.J.* ; Johnson, T.R.C.*

X-ray fluorescence molecular imaging of high-Z tracers: Investigation of a novel analyzer based setup.

Proc. SPIE 9033:90331J (2014)

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Open Access Green as soon as Postprint is submitted to ZB.

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A novel x-ray fluorescence imaging setup for The in vivo detection of high-Z Tracer distributions is investigated for its application in molecular imaging. The setup uses an energy resolved detection method based on a Bragg reflecting analyzer array Together with a multiple scatter reducing radial collimator. The aim of This work is To investigate The potential application of This imaging method To in vivo imaging in humans. A proof of principle experiment modeling a partial setup for The detection of gold nano-particles was conducted in order To Test The feasibility of The proposed imaging method. Furthermore a Monte Carlo simulation of The complete setup was created in order To quantify The dependence of The image quality on The applied radiation dose and on The geometrical collimator parameters as well as on The analyzer crystal parameters. The Monte Carlo simulation quantifies The signal-to-noise ratio per radiation dose and its dependence on The collimator parameters. Thereby The parameters needed for a dose efficient in vivo imaging of gold nano-particle based Tracer distributions are quantified. However also a number of problems are found like The fluorescence emission as well as scatter from The collimator material obscuring The Tracer fluorescence and The potentially large scan Time.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Geant4 Simulation ; Gold Nanoparticles ; High-z Tracers ; Molecular Imaging ; X-ray Fluorescence

ISSN (print) / ISBN 0277-786X

e-ISSN 1996-756X

Conference Title Medical Imaging 2014: Physics of Medical Imaging

Conference Date 17-20 February 2014

Conference Location San Diego, CA

Journal Proceedings of SPIE

Quellenangaben Volume: 9033, Article Number: 90331J

Publisher SPIE

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Research Unit Medical Radiation Physics and Diagnostics (AMSD)