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Ultrawideband reflection-mode optoacoustic mesoscopy.
Opt. Lett. 39, 3911-3914 (2014)
We developed a reflection-mode optoacoustic mesoscopy system, based on raster-scanning of a custom designed spherically focused ultrasound detector, enabling seamless epi-illumination of the volume imaged. We study the performance of acoustic-resolution mesoscopy operating at an ultrawideband bandwidth of 20–180 MHz. i.e., a frequency band spreading over virtually an order of magnitude. Using tomographic reconstruction we showcase previously unreported, to our knowledge, axial resolutions of 4 μm and transverse resolutions of 18 μm reaching depths of up to 5 mm. We further investigate the frequency-dependence of features seen on the images to understand the implications of ultrawideband measurements. We show the overall imaging performance and the frequency ranges that contribute to observable resolution improvements from phantoms and animals.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Photoacoustic Microscopy; Resolution
Language
english
Publication Year
2014
HGF-reported in Year
2014
ISSN (print) / ISBN
0146-9592
e-ISSN
1539-4794
Journal
Optics Letters
Quellenangaben
Volume: 39,
Issue: 13,
Pages: 3911-3914
Publisher
Optical Society of America (OSA)
Publishing Place
Washington
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-505500-001
WOS ID
WOS:000338933200056
Scopus ID
84903647853
Erfassungsdatum
2014-07-01