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Bakolis, I.* ; Heinrich, J. ; Zock, J.P.* ; Norbäck, D.* ; Svanes, C.* ; Chen, C.M. ; Accordini, S.* ; Verlato, G.E.* ; Olivieri, M.* ; Jarvis, D.L.*

House dust-mite allergen exposure is associated with serum specific IgE but not with respiratory outcomes.

Indoor Air 25, 235-244 (2015)

DOI

Open Access Green as soon as Postprint is submitted to ZB.

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Exposure to house dust has been associated with asthma in adults, and this is commonly interpreted as a direct immunologic response to dust-mite allergens in those who are IgE sensitized to house dust-mite. Mattress house dust-mite concentrations were measured in a population-based sample of 2890 adults aged between 27 and 56 years living in 22 centers in 10 countries. Generalized linear mixed models were employed to explore the association of respiratory symptoms with house dust-mite concentrations, adjusting for individual and household confounders. There was no overall association of respiratory outcomes with measured house dust-mite concentrations, even in those who reported they had symptoms on exposure to dust and those who had physician-diagnosed asthma. However, there was a positive association of high serum specific IgE levels to HDM (>3.5 kUA/l) with mattress house dust-mite concentrations and a negative association of sensitization to cat with increasing house dust-mite concentrations. In conclusion, there was no evidence that respiratory symptoms in adults were associated with exposure to house dust-mite allergen in the mattress, but an association of house mite with strong sensitization was observed. © 2014 John Wiley & Sons A/S.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Asthma ; Ecrhs ; House Dust-mite Concentrations ; Lung Function; Health Survey-ii; Bronchial Responsiveness; Childhood Asthma; Cat Allergens; Children; Homes; Sensitization; Metaanalysis; Community; Sample

ISSN (print) / ISBN 0905-6947

e-ISSN 1600-0668

Journal Indoor Air

Quellenangaben Volume: 25, Issue: 3, Pages: 235-244

Publisher Wiley

Publishing Place Hoboken

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology (EPI)