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Open Access Green as soon as Postprint is submitted to ZB.
Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing.
Phys. Med. Biol. 59, 4785-4797 (2014)
Chromophore quantification in optoacoustic tomography is challenging due to signal contributions from strongly absorbing background tissue chromophores and the depth-dependent light attenuation. Herein we present a procedure capable of correcting for wavelength-dependent light fluence variations using a logarithmic representation of the images taken at different wavelengths assisted with a blind unmixing approach. It is shown that the serial expansion of the logarithm of an optoacoustic image contains a term representing the ratio between absorption of the probe of interest and other background components. Under assumptions of tissue-like background absorption variations, this term can be readily isolated with an unmixing algorithm, attaining quantitative maps of photo-absorbing agent distribution.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Multispectral Unmixing ; Optoacoustic Probes ; Optoacoustic Tomography ; Quantitative Imaging; In-vivo; Reconstruction Algorithm; Photoacoustic Microscopy; Scattering Media; High-resolution; Tomography
ISSN (print) / ISBN
0031-9155
e-ISSN
1361-6560
Journal
Physics in Medicine and Biology
Quellenangaben
Volume: 59,
Issue: 17,
Pages: 4785-4797
Publisher
Institute of Physics Publishing (IOP)
Publishing Place
Bristol
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)