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MRNA transport meets membrane traffic.
Trends Genet. 30, 408-417 (2014)
Active transport and local translation of mRNAs ensure the appropriate spatial organization of proteins within cells. Recent work has shown that this process is intricately connected to membrane trafficking. Here, we focus on new findings obtained in fungal model systems. Important highlights are that RNA-binding proteins recognize cargo mRNA synergistically and that mRNAs are co-transported with membranous compartments such as the endoplasmic reticulum (ER) and endosomes. We further discuss a novel concept of endosome-coupled translation that loads shuttling endosomes with septin cargo, a process important for correct septin filamentation. Interestingly, evidence is accumulating that RNA and membrane trafficking are also tightly interwoven in higher eukaryotes, suggesting that this phenomenon is a common theme and not an exception restricted to fungi.
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Publication type
Article: Journal article
Document type
Review
Keywords
Actin ; Endoplasmic Reticulum ; Endosomes ; Microtubule ; Mrnp ; Septin
ISSN (print) / ISBN
0168-9479
Journal
Trends in Genetics
Quellenangaben
Volume: 30,
Issue: 9,
Pages: 408-417
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)