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Kraus, P.* ; Sivakamasundari, V.* ; Yu, H.B.* ; Xing, X.* ; Lim, S.L.* ; Adler, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Bohla, A. ; Garrett, L. ; Hans, W. ; Hölter, S.M. ; Janas, E. ; Moreth, K. ; Prehn, C. ; Puk, O. ; Rathkolb, B. ; Rozman, J. ; Adamski, J. ; Bekeredjian, R. ; Busch, D.H. ; Graw, J. ; Klingenspor, M. ; Klopstock, T. ; Neff, F. ; Ollert, M. ; Stöger, T. ; Yildirim, A.Ö. ; Eickelberg, O. ; Wolf, E. ; Wurst, W. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Lufkin, T.* ; Stanton, L.W.*

Pleiotropic functions for transcription factor Zscan10.

PLoS ONE 9:e104568 (2014)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye malformation previously described for Sox2 hypomorphs. Phenotypic abnormalities are supported by the nature of Zscan10 expression in midgestation embryos and adults suggesting a role for Zscan10 in either maintaining progenitor cell subpopulation or impacting on fate choice decisions thereof.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Embryonic Stem-cells; Platelet Production; Gene-expression; Nervous-system; Mouse Embryos; Germ-line; Sox2; Pax6; Eye; Differentiation
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 9, Issue: 8, Pages: , Article Number: e104568 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Developmental Genetics (IDG)
Institute of Pathology (PATH)
Institute of Molecular Immunology (IMI)
Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30201 - Metabolic Health
30204 - Cell Programming and Repair
90000 - German Center for Diabetes Research
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
Immune Response and Infection
Lung Research
PSP Element(s) G-500600-001
G-500600-003
G-505600-001
G-500500-001
G-500500-002
G-501900-066
G-500300-001
G-501790-003
G-505000-001
G-505000-007
G-501600-001
G-505000-006
PubMed ID 25111779
DOI 10.1371/journal.pone.0104568
WOS ID WOS:000341105100075
Scopus ID 84905833836
Erfassungsdatum 2014-08-13
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