PuSH - Publication Server of Helmholtz Zentrum München: Quality control and conduct of genome-wide association meta-analyses.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Winkler, T.W.* ; Day, F.R.* ; Croteau-Chonka, D.C.* ; Wood, A.R.* ; Locke, A.E.* ; Mägi, R.* ; Ferreira, T.* ; Fall, T.* ; Graff, M.* ; Justice, A.E.* ; Luan, J.* ; Gustafsson, S.* ; Randall, J.C.* ; Vedantam, S.* ; Workalemahu, T.* ; Kilpeläinen, T.O.* ; Scherag, A.* ; Esko, T.* ; Kutalik, Z.* ; Heid, I.M. ; Loos, R.J.* ; GIANT Consortium (Albrecht, E. ; Müller-Nurasyid, M. ; Grallert, H. ; Peters, A. ; Thorand, B. ; Gieger, C. ; Illig, T. ; Wichmann, H.-E.)

Quality control and conduct of genome-wide association meta-analyses.

Nat. Protoc. 9, 1192-1212 (2014)

DOI

PMC

Open Access Green as soon as Postprint is submitted to ZB.

Abstract
Metrics
Extra information

Rigorous organization and quality control (QC) are necessary to facilitate successful genome-wide association meta-analyses (GWAMAs) of statistics aggregated across multiple genome-wide association studies. This protocol provides guidelines for (i) organizational aspects of GWAMAs, and for (ii) QC at the study file level, the meta-level across studies and the meta-analysis output level. Real-world examples highlight issues experienced and solutions developed by the GIANT Consortium that has conducted meta-analyses including data from 125 studies comprising more than 330,000 individuals. We provide a general protocol for conducting GWAMAs and carrying out QC to minimize errors and to guarantee maximum use of the data. We also include details for the use of a powerful and flexible software package called EasyQC. Precise timings will be greatly influenced by consortium size. For consortia of comparable size to the GIANT Consortium, this protocol takes a minimum of about 10 months to complete.

Impact Factor

Scopus SNIP

Web of Science
Times Cited

Scopus
Cited By

Altmetric

7.782

2.315

218