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DIMA 2.0 - predicted and known domain interactions.
Nucleic Acids Res. 36, D651-655 (2008)
DIMA-the domain interaction map has evolved from a simple web server for domain phylogenetic profiling into an integrative prediction resource combining both experimental data on domain-domain interactions and predictions from two different algorithms. With this update, DIMA obtains greatly improved coverage at the level of genomes and domains as well as with respect to available prediction approaches. The domain phylogenetic profiling method now uses SIMAP as its backend for exhaustive domain hit coverage: 7038 Pfam domains were profiled over 460 completely sequenced genomes.Domain pair exclusion predictions were produced from 83 969 distinct protein-protein interactions obtained from IntAct resulting in 21 513 domain pairs with significant domain pair exclusion algorithm scores. Additional predictions applying the same algorithm to predicted protein interactions from STRING yielded 2378 high-confidence pairs. Experimental data comes from iPfam (3074) and 3did (3034 pairs), two databases identifying domain contacts in solved protein structures. Taken together, these two resources yielded 3653 distinct interacting domain pairs. DIMA is available at http://mips.gsf.de/genre/proj/dima.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
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6.954
2.440
14
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
DIMA 2.0; domain interaction map; PROTEIN-PROTEIN INTERACTIONS; INTERACTION DATABASE; RESOURCE; NETWORKS; FEATURES; PDB
Language
english
Publication Year
2008
HGF-reported in Year
0
ISSN (print) / ISBN
0305-1048
e-ISSN
1362-4962
Journal
Nucleic Acids Research
Quellenangaben
Volume: 36,
Issue: SI,
Pages: D651-655
Publisher
Oxford University Press
Reviewing status
Peer reviewed
POF-Topic(s)
30505 - New Technologies for Biomedical Discoveries
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-503700-001
PubMed ID
17999995
DOI
101.093
WOS ID
000252545400117
Erfassungsdatum
2008-07-30