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The role of α-E-catenin in cerebral cortex development: Radial glia specific effect on neuronal migration.
Front. Cell. Neurosci. 8:215 (2014)
During brain development, radial glial cells possess an apico-basal polarity and are coupled by adherens junctions (AJs) to an F-actin belt. To elucidate the role of the actin, we conditionally deleted the key component α-E-catenin in the developing cerebral cortex. Deletion at early stages resulted in severe disruption of tissue polarity due to uncoupling of AJs with the intracellular actin fibers leading to the formation of subcortical band heterotopia. Interestingly, this phenotype closely resembled the phenotype obtained by conditional RhoA deletion, both in regard to the macroscopic subcortical band heterotopia and the subcellular increase in G-actin/F-actin ratio. These data therefore together corroborate the role of the actin cytoskeleton and its anchoring to the AJs for neuronal migration disorders.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Actin ; Adherens Junctions ; Cell Polarity ; Neuronal Migration ; Subcortical Band Heterotopia ; α-e-catenin; Progenitor Cells; Beta-catenin; N-catenin; Cortical Development; Subventricular Zone; Neural Progenitors; Adherens Junctions; Pyramidal Neurons; Epithelial-cells; Apical Surface
e-ISSN
1662-5102
Quellenangaben
Volume: 8,
Article Number: 215
Publisher
Frontiers
Publishing Place
Lausanne
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)