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Quarta, C. ; Mazza, R.* ; Obici, S.* ; Pasquali, R.* ; Pagotto, U.*

Energy balance regulation by endocannabinoids at central and peripheral levels.

Trends Mol. Med. 17, 518-526 (2011)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Dysregulation of the endocannabinoid system (ECS) is a universal and, perhaps, causative feature of obesity. Central nervous system (CNS) circuits that regulate food intake were initially believed to be the targets for dysregulation. However, it is increasingly evident that endocannabinoids affect food intake, energy expenditure and substrate metabolism by acting on peripheral sites. Cannabinoid type 1 receptor (CB1r) antagonists can effectively treat obesity and associated metabolic alterations but, unfortunately, cause and exacerbate mood disorders. Drugs restricted to act on peripheral CB1rs might be safer and more effective, retaining the anti-obesity effects but lacking the adverse neurodepressive reactions. This review summarizes the emerging roles of the ECS in energy balance and discusses future pharmacological approaches for developing peripherally restricted CB1r antagonists.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2011
HGF-reported in Year 0
ISSN (print) / ISBN 1471-4914
e-ISSN 1471-499X
Journal Trends in Molecular Medicine
Quellenangaben Volume: 17, Issue: 9, Pages: 518-526 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
PubMed ID 21816675
DOI 10.1016/j.molmed.2011.05.002
Erfassungsdatum 2011-12-31
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