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Gross, C.* ; Holler, E.* ; Stangl, S. ; Dickinson, A.* ; Pockley, A.G. ; Asea, A.A.* ; Mallappa, N.* ; Multhoff, G.

An Hsp70 peptide initiates NK cell killing of leukemic blasts after stem cell transplantation.

Leuk. Res. 32, 527-537 (2008)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
In contrast to solid tumors, leukemic blasts frequently present both Hsp70 and HLA-E on their cell surface and thereby present activating and inhibitory signals to CD94(+) NK cells. In the first 12 months after stem cell transplantation (SCT) CD94(+) NK cells clearly dominate over CD3(+)/CD16(-)/56(-) T and CD3(+)/CD16(+)/56(+) NK-like T cells. An incubation of post-SCT-derived peripheral blood lymphocytes with the Hsp70 peptide TKD and IL-15 enhances the cell surface density of CD56/CD94 and initiates the cytolytic activity of NK cells against Hsp70/HLA-E double-positive autologous and allogeneic leukemic blasts. Hsp70 was identified as the target structure for TKD-activated NK cells.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hsp70 peptide TKD; HLA-E; NK cells; Stem cell transplantation; Cytotoxicity
Language english
Publication Year 2008
HGF-reported in Year 0
ISSN (print) / ISBN 0145-2126
e-ISSN 1873-5835
Journal Leukemia Research
Quellenangaben Volume: 32, Issue: 4, Pages: 527-537 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) CCG Innate Immunity in Tumor Biology (PATH-KTB)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
PSP Element(s) G-521400-001
PubMed ID 17543383
DOI 10.1016/j.leukres.2007.03.027
WOS ID 000254724300003
Erfassungsdatum 2008-03-14
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