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Ussar, S. ; Lee, K.Y.* ; Dankel, S.N.* ; Boucher, J.* ; Haering, M.-F.* ; Kleinridders, A.* ; Thomou, T.* ; Xue, R.* ; Macotela, Y.* ; Cypess, A.M.* ; Tseng, Y.H.* ; Mellgren, G.* ; Kahn, C.R.*

ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.

Sci. Transl. Med. 6:245ra94 (2014)
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White, beige, and brown adipocytes are developmentally and functionally distinct but often occur mixed together within individual depots. To target white, beige, and brown adipocytes for diagnostic or therapeutic purposes, a better understanding of the cell surface properties of these cell types is essential. Using a combination of in silico, in vitro, and in vivo methods, we have identified three new cell surface markers of adipose cell types. The amino acid transporter ASC-1 is a white adipocyte-specific cell surface protein, with little or no expression in brown adipocytes, whereas the amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes in mice. These markers also selectively mark brown/beige and white adipocytes in human tissue. Thus, ASC-1, PAT2, and P2RX5 are membrane surface proteins that may serve as tools to identify and target white and brown/beige adipocytes for therapeutic purposes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adipose-tissue; Adult Humans; Messenger-rna; Amino-acids; Fat-cell; D-serine; Expression; Obesity; Mouse; Identification
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1946-6234
e-ISSN 1946-6242
Journal Science Translational Medicine
Quellenangaben Volume: 6, Issue: 245, Pages: , Article Number: 245ra94 Supplement: ,
Publisher American Association for the Advancement of Science (AAAS)
Publishing Place Washington
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30502 - Diabetes: Pathophysiology, Prevention and Therapy
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-508600-003
PubMed ID 25080478
DOI 10.1126/scitranslmed.3008490
WOS ID WOS:000339661500011
Erfassungsdatum 2014-09-01
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