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Open Access Green as soon as Postprint is submitted to ZB.
ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes.
Sci. Transl. Med. 6:245ra94 (2014)
White, beige, and brown adipocytes are developmentally and functionally distinct but often occur mixed together within individual depots. To target white, beige, and brown adipocytes for diagnostic or therapeutic purposes, a better understanding of the cell surface properties of these cell types is essential. Using a combination of in silico, in vitro, and in vivo methods, we have identified three new cell surface markers of adipose cell types. The amino acid transporter ASC-1 is a white adipocyte-specific cell surface protein, with little or no expression in brown adipocytes, whereas the amino acid transporter PAT2 and the purinergic receptor P2RX5 are cell surface markers expressed in classical brown and beige adipocytes in mice. These markers also selectively mark brown/beige and white adipocytes in human tissue. Thus, ASC-1, PAT2, and P2RX5 are membrane surface proteins that may serve as tools to identify and target white and brown/beige adipocytes for therapeutic purposes.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adipose-tissue; Adult Humans; Messenger-rna; Amino-acids; Fat-cell; D-serine; Expression; Obesity; Mouse; Identification
ISSN (print) / ISBN
1946-6234
e-ISSN
1946-6242
Journal
Science Translational Medicine
Quellenangaben
Volume: 6,
Issue: 245,
Article Number: 245ra94
Publisher
American Association for the Advancement of Science (AAAS)
Publishing Place
Washington
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)