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Adam, M.* ; Schikowski, T.* ; Carsin, A.E.* ; Cai, Y.* ; Jacquemin, B.* ; Sanchez, M.* ; Vierkötter, A.* ; Marcon, A.* ; Keidel, D.* ; Sugiri, D.* ; Al Kanani, Z.* ; Nadif, R.* ; Siroux, V.* ; Hardy, R.* ; Kuh, D.* ; Rochat, T.* ; Bridevaux, P.O.* ; Eeftens, M.* ; Tsai, M.Y.* ; Villani, S.* ; Phuleria, H.C.* ; Birk, M. ; Cyrys, J. ; Cirach, M.* ; de Nazelle, A.* ; Nieuwenhuijsen, M.J.* ; Forsberg, B.* ; de Hoogh, K.* ; Declerq, C.* ; Bono, R.* ; Piccioni, P.* ; Quass, U.* ; Heinrich, J. ; Jarvis, D.* ; Pin, I.* ; Beelen, R.* ; Hoek, G.* ; Brunekreef, B.* ; Schindler, C.* ; Sunyer, J.* ; Krämer, U.* ; Kauffmann, F.* ; Hansell, A.L.* ; Künzli, N.* ; Probst-Hensch, N.*

Adult lung function and long-term air pollution exposure. ESCAPE: A multicentre cohort study and meta-analysis.

Eur. Respir. J. 45, 38-50 (2015)
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The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NOx) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 μg·m(-3) increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95%CI -25.8- -2.1) and FVC (-14.9 mL, 95% CI -28.7- -1.1). An increase of 10 μg·m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4- -3.8) and FVC (-59.0 mL, 95% CI -112.3- -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Use Regression-models; Body-mass Index; Pm2.5 Absorbency; Function Decline; Ozone Exposure; Obesity; No2; Project; Areas; Inflammation
Language english
Publication Year 2015
Prepublished in Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 45, Issue: 1, Pages: 38-50 Article Number: , Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503900-001
G-504000-004
PubMed ID 25193994
DOI 10.1183/09031936.00130014
WOS ID WOS:000348179800010
Scopus ID 84920612590
Erfassungsdatum 2014-09-08
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