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Kirchner, H.* ; Gutierrez, J.A.* ; Solenberg, P.J.* ; Pfluger, P.T.* ; Czyzyk, T.A.* ; Willency, J.A.* ; Schürmann, A.* ; Joost, H.G.* ; Jandacek, R.J.* ; Hale, J.E.* ; Heiman, M.L.* ; Tschöp, M.H.*

GOAT links dietary lipids with the endocrine control of energy balance.

J. Nat. Med. 15, 741-5 (2009)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Central nervous system nutrient sensing and afferent endocrine signaling have been established as parallel systems communicating metabolic status and energy availability in vertebrates. The only afferent endocrine signal known to require modification with a fatty acid side chain is the orexigenic hormone ghrelin. We find that the ghrelin O-acyl transferase (GOAT), which is essential for ghrelin acylation, is regulated by nutrient availability, depends on specific dietary lipids as acylation substrates and links ingested lipids to energy expenditure and body fat mass. These data implicate the ghrelin-GOAT system as a signaling pathway that alerts the central nervous system to the presence of dietary calories, rather than to their absence as is commonly accepted.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 1340-3443
e-ISSN 1861-0293
Journal Journal of natural medicines
Quellenangaben Volume: 15, Issue: 7, Pages: 741-5 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Tokyo [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)