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Open Access Gold as soon as Publ. Version/Full Text is submitted to ZB.
Endogenous glucagon regulation in genetically hyperlipemic obese rats.
Am. J. Physiol.-Cell Physiol. 230, 1336-41 (1976)
Glucagon concentration and regulation were examined in the Zucker rat, in which obesity and hyperlipemia are phenotypic expressions of an autosomal recessive gene. Using littermate animals which are phenotypically thin and normolipemic as controls, we observed reduced basal plasma glucagon levels in the obese lipemic rats. In response to fasting, obese lipemic animals inappropriately demonstrated a further reduction in plasma glucagon concentration. In response to pharmacologic glucagon stimulation (arginine), a subnormal rise in plasma glucagon concentration was observed in the obese, lipemic animals. Glucagon suppressibility with exogenous glucose remained intact. The reduced secretion of glucagon may be a consequence of the abnormal elevation in concentration of plasma insulin, free fatty acids, and glucose, which are characteristic of the obese, lipemic animal. A possible role of glucagon deficiency in the evolution or maintenance of the lipemic state is suggested.
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Publication type
Article: Journal article
Document type
Scientific Article
Language
english
Publication Year
1976
HGF-reported in Year
0
ISSN (print) / ISBN
0363-6143
e-ISSN
1522-1563
Quellenangaben
Volume: 230,
Issue: 5,
Pages: 1336-41
Publisher
American Physiological Society
Reviewing status
Peer reviewed
PubMed ID
1275076
Erfassungsdatum
1976-05-00