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Viskari, H.* ; Ludvigsson, J.* ; Uibo, R.* ; Salur, L.* ; Marciulionyte, D.* ; Hermann, R.* ; Soltesz, G.* ; Füchtenbusch, M.* ; Ziegler, A.-G.* ; Kondrashova, A.* ; Romanov, A.* ; Kaplan, B.* ; Laron, Z.* ; Koskela, P.* ; Vesikari, T.* ; Huhtala, H.* ; Knip, M.* ; Hyoty, H.*

Relationship between the incidence of type 1 diabetes and maternal enterovirus antibodies: time trends and geographical variation.

Diabetologia 48, 1280-1287 (2005)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIMS/HYPOTHESIS: We have previously observed an inverse correlation between the incidence of type 1 diabetes and enterovirus infections in the background population. The aim of this study was to analyse whether maternal enterovirus antibody status, which reflects both the frequency of enterovirus infections and the protection conferred by the mother on the offspring, also correlates with the incidence of type 1 diabetes. METHODS: Maternal enterovirus antibodies were analysed from serum samples taken from pregnant women between 1983 and 2001 in Finland and Sweden using enzyme immunoassay and neutralisation assays. Comparable samples were also taken between 1999 and 2001 in countries with a lower incidence of diabetes (Estonia, Germany, Hungary, Israel, Lithuania, Russia). RESULTS: A clear decrease was observed in maternal enterovirus antibody levels over the past 20 years (p<0.0001). The frequency of enterovirus antibodies was higher in countries with a low or intermediate incidence of type 1 diabetes compared with high-incidence countries (p<0.0001). CONCLUSIONS/INTERPRETATION: These findings are in line with our previous observations supporting the hypothesis that a low frequency of enterovirus infection in the background population increases the susceptibility of young children to the diabetogenic effect of enteroviruses.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 0012-186X
e-ISSN 1432-0428
Journal Diabetologia
Quellenangaben Volume: 48, Issue: 7, Pages: 1280-1287 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin ; Heidelberg [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)