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Achenbach, P.* ; Bonifacio, E.* ; Koczwara, K.* ; Ziegler, A.-G.*

Natural history of type 1 diabetes.

Diabetes 54, S25-S31 (2005)
Open Access Green as soon as Postprint is submitted to ZB.
The natural history of autoimmune type 1 diabetes in children is associated with the appearance of islet autoantibodies early in life, which is influenced by genetic and environmental factors. Once islet autoantibodies have developed, the progression to diabetes in antibody-positive individuals is determined by the age of antibody appearance and by the magnitude of the autoimmunity, in turn related to the age of the subject. Characteristics that describe the magnitude of the autoimmunity can stage progression to type 1 diabetes in islet autoantibody–positive subjects regardless of genetic background or age.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2005
HGF-reported in Year 0
ISSN (print) / ISBN 0012-1797
e-ISSN 1939-327X
Journal Diabetes
Quellenangaben Volume: 54, Issue: S2, Pages: S25-S31 Article Number: , Supplement: ,
Publisher American Diabetes Association
Publishing Place Alexandria, VA.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
Institute of Diabetes and Obesity (IDO)
Institute of Pancreatic Islet Research (IPI)
POF-Topic(s) 30201 - Metabolic Health
30502 - Diabetes: Pathophysiology, Prevention and Therapy
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
G-502290-001
Erfassungsdatum 2005-12-31