PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Keymeulen, B.* ; Candon, S.* ; Fafi-Kremer, S.* ; Ziegler, A.* ; Leruez-Ville, M.* ; Mathieu, C.* ; Vandemeulebroucke, E.* ; Walter, M.* ; Crenier, L.* ; Thervet, E.* ; Legendre, C.* ; Pierard, D.* ; Hale, G.* ; Waldmann, H.* ; Bach, J.F.* ; Seigneurin, J.M.* ; Pipeleers, D.* ; Chatenoud, L.*

Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.

Blood 115, 1145-55 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Here we report a unique situation in which an early and synchronized Epstein-Barr virus (EBV) reactivation was induced by a 6-day course of treatment with a humanized CD3-specific monoclonal antibody in patients with recent onset of type 1 diabetes. The virologic and immunologic analysis demonstrated that this reactivation was transient, self-limited, and isolated, associated with the rapid advent of an EBV-specific T-cell response. The anti-CD3 antibody administration induced short-lasting immunosuppression and minor yet clear-cut signs of T-cell activation that preceded viral reactivation. Early posttransplant monitoring of renal and islet allograft recipients showed that no comparable phenomenon was observed after the administration of full-dose immunosuppressive therapy. This EBV reactivation remains of no apparent clinical concern over the long term and should not preclude further development of therapeutic anti-CD3 antibodies. This phenomenon may also direct new research avenues to understand the still ill-defined nature of stimuli triggering EBV reactivation in vivo.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
0.000
3.040
54
60
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2010
HGF-reported in Year 0
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Journal Blood
Quellenangaben Volume: 115, Issue: 6, Pages: 1145-55 Article Number: , Supplement: ,
Publisher American Society of Hematology
Publishing Place Washington, DC
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research (IDF)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502100-001
PubMed ID 20007541
DOI 10.1182/blood-2009-02-204875
WOS ID 000274431400009
Erfassungsdatum 2009-12-09
[➜Report correction]