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Dlugaj, M.* ; Weimar, C.* ; Wege, N.* ; Verde, P.E.* ; Gerwig, M.* ; Dragano, N.* ; Moebus, S.* ; Jöckel, K.-H.* ; Erbel, R.* ; Siegrist, J.* ; Heinz Nixdorf Recall Study Cohort (Löwel, H.)

Prevalence of mild cognitive impairment and its subtypes in the Heinz Nixdorf Recall study cohort.

Dement. Geriatr. Cogn. Disord. 30, 362-373 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIMS: We investigated the prevalence of mild cognitive impairment (MCI) and its subtypes according to the original (MCI-original) and modified (MCI-modified; neglecting cognitive complaints) Petersen criteria. METHODS: 4,145 subjects (aged 50-80 years) from a German population-based study completed a cognitive screening test and were poststratified into 2 groups with sample sizes of 1,125 for impaired and 3,020 for age-appropriate performance. Random samples of 445 impaired participants and 211 age-appropriate participants received a detailed neuropsychological evaluation. The prevalence of MCI was estimated by a bias correction estimator based on stratum weights. The association between MCI and age, gender and education was analyzed in a logistic regression model. RESULTS: The estimated MCI prevalence was 7.8% (95% CI: 5.7-9.9%) for the original, and 12.1% (95% CI: 9.8-14.4%) for the modified criteria. In the MCI-original group, amnestic MCI subtypes were slightly less common than non-amnestic MCI subtypes (3.5 vs. 4.3%). MCI-original was associated with lower education and older age. In the MCI-modified group, the amnestic subtypes were more common than the non-amnestic MCI subtypes (7.8 vs. 4.3%), and MCI was associated with age, gender and education. CONCLUSIONS: Prevalence rates of MCI are high in the general population and vary considerably according to the criteria applied.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1420-8008
e-ISSN 1421-9824
Journal Dementia and Geriatric Cognitive Disorders
Quellenangaben Volume: 30, Issue: 4, Pages: 362-373 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Basel ; Freiburg [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)