PuSH - Publication Server of Helmholtz Zentrum München

Franke, A.* ; Balschun, T.* ; Sina, C.* ; Ellinghaus, D.* ; Häsler, R.* ; Mayr, G.* ; Albrecht, M.* ; Wittig, M.* ; Buchert, E.* ; Nikolaus, S.* ; Gieger, C. ; Wichmann, H.-E. ; Sventoraityte, J.* ; Kupcinskas, L.* ; Onnie, C.M.* ; Gazouli, M.* ; Anagnou, N.P.* ; Strachan, D.* ; McArdle, W.L.* ; Mathew, C.G.* ; Rutgeerts, P.* ; Vermeire, S.* ; Vatn, M.H.* ; Krawczak., M.* ; Rosenstiel, P.* ; Karlsen, T.H.* ; Schreiber, S.*

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

Nat. Genet. 42, 292-294 (2010)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Inflammatory-bowel-disease; Susceptibility; BTNL2
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 42, Issue: 4, Pages: 292-294 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)