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Rogowski, W.H. ; Payne, K.* ; Schnell-Inderst, P.* ; Manca, A.* ; Rochau, U.* ; Jahn, B.* ; Alagoz, O.* ; Leidl, R. ; Siebert, U.*

Concepts of 'personalization' in personalized medicine: Implications for economic evaluation.

Pharmacoeconomics 33, 49-59 (2015)
Postprint DOI PMC
Open Access Green
CONTEXT: This study assesses if, and how, existing methods for economic evaluation are applicable to the evaluation of personalized medicine (PM) and, if not, where extension to methods may be required. METHODS: A structured workshop was held with a predefined group of experts (n = 47), and was run using a modified nominal group technique. Workshop findings were recorded using extensive note taking, and summarized using thematic data analysis. The workshop was complemented by structured literature searches. RESULTS: The key finding emerging from the workshop, using an economic perspective, was that two distinct, but linked, interpretations of the concept of PM exist (personalization by 'physiology' or 'preferences'). These interpretations involve specific challenges for the design and conduct of economic evaluations. Existing evaluative (extra-welfarist) frameworks were generally considered appropriate for evaluating PM. When 'personalization' is viewed as using physiological biomarkers, challenges include representing complex care pathways; representing spillover effects; meeting data requirements such as evidence on heterogeneity; and choosing appropriate time horizons for the value of further research in uncertainty analysis. When viewed as tailoring medicine to patient preferences, further work is needed regarding revealed preferences, e.g. treatment (non)adherence; stated preferences, e.g. risk interpretation and attitude; consideration of heterogeneity in preferences; and the appropriate framework (welfarism vs. extra-welfarism) to incorporate non-health benefits. CONCLUSIONS: Ideally, economic evaluations should take account of both interpretations of PM and consider physiology and preferences. It is important for decision makers to be cognizant of the issues involved with the economic evaluation of PM to appropriately interpret the evidence and target future research funding.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2015
Prepublished in Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1170-7690
e-ISSN 1179-2027
Journal PharmacoEconomics
Quellenangaben Volume: 33, Issue: 1, Pages: 49-59 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-505300-001
DOI 10.1007/s40273-014-0211-5
WOS ID WOS:000347152700006
Scopus ID 84922006725
Scopus ID 84908519235
PubMed ID 25249200
Erfassungsdatum 2014-09-26
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