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Signaling in adult neurogenesis: From stem cell niche to neuronal networks.

Curr. Opin. Neurobiol. 17, 338-344 (2007)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The mechanisms that determine why neurogenesis is restricted to few regions of the adult brain in mammals, in contrast to its more widespread nature in other vertebrates such as zebrafish, remain to be fully understood. The local environment must provide key signals that instruct stem cell and neurogenic fate, because non-neurogenic progenitors can be instructed towards neurogenesis in this environment. Here, we discuss the recent progress in understanding key factors in the local stem cell niche of the adult mammalian brain, including surprising sources of new signals such as endothelial cells, complement factors and microglia. Moreover, new insights have been gained into how neuronal diversity is instructed in adult neurogenesis, prompting a new view of stem and progenitor cell heterogeneity in the adult mammalian brain.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2007
HGF-reported in Year 2007
ISSN (print) / ISBN 0959-4388
e-ISSN 1873-6882
Quellenangaben Volume: 17, Issue: 3, Pages: 338-344 Article Number: , Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
PubMed ID 17475475
Scopus ID 34250029182
Erfassungsdatum 2007-05-01