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Jeltsch, K. ; Hu, D. ; Brenner, S. ; Zöller, J. ; Heinz, G.A. ; Nagel, D. ; Vogel, K.U. ; Rehage, N. ; Warth, S.C. ; Edelmann, S.L. ; Gloury, R.* ; Martin, N. ; Lohs, C. ; Lech, M.* ; Stehklein, J.E. ; Geerlof, A. ; Kremmer, E. ; Weber, A.* ; Anders, H.J.* ; Schmitz, I.* ; Schmidt-Supprian, M.* ; Fu, M.* ; Holtmann, H.* ; Krappmann, D. ; Ruland, J.* ; Kallies, A.* ; Heikenwälder, M. ; Heissmeyer, V.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.

Nat. Immunol. 15, 1079-1089 (2014)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Humoral autoimmunity paralleled by the accumulation of follicular helper T cells (TFH cells) is linked to mutation of the gene encoding the RNA-binding protein roquin-1. Here we found that T cells lacking roquin caused pathology in the lung and accumulated as cells of the TH17 subset of helper T cells in the lungs. Roquin inhibited TH17 cell differentiation and acted together with the endoribonuclease regnase-1 to repress target mRNA encoding the TH17 cell-promoting factors IL-6, ICOS, c-Rel, IRF4, IκBNS and IκBζ. This cooperation required binding of RNA by roquin and the nuclease activity of regnase-1. Upon recognition of antigen by the T cell antigen receptor (TCR), roquin and regnase-1 proteins were cleaved by the paracaspase MALT1. Thus, this pathway acts as a 'rheostat' by translating TCR signal strength via graded inactivation of post-transcriptional repressors and differential derepression of targets to enhance TH17 differentiation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Nf-kappa-b; Messenger-rna Decay; Helper T-cells; Transcription Factor; Pharmacological Inhibition; Protease Activity; Protects Mice; T-h-17 Cells; Activation; Autoimmunity
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 15, Issue: 11, Pages: 1079-1089 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Immunology (IMI)
Institute of Virology (VIRO)
Research Unit Signaling and Translation (SAT)
Institute of Molecular Toxicology and Pharmacology (TOX)
Institute of Structural Biology (STB)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
Enabling and Novel Technologies
PSP Element(s) G-501792-001
G-551600-001
G-509800-002
G-501793-001
G-505200-001
G-501790-001
G-503000-003
PubMed ID 25282160
DOI 10.1038/ni.3008
WOS ID WOS:000343640700014
Scopus ID 84908209291
Erfassungsdatum 2014-10-07
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