Freitag-Wolf, S.* ; Dommisch, H.* ; Graetz, C.* ; Jockel-Schneider, Y.* ; Harks, I.* ; Staufenbiel, I.* ; Meyle, J.* ; Eickholz, P.* ; Noack, B.* ; Bruckmann, C.* ; Gieger, C. ; Jepsen, S.* ; Lieb, W.* ; Schreiber, S.* ; König, I.R.* ; Schäfer, A.S.*
Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men.
J. Clin. Periodontol. 41, 1115-1121 (2014)
AIM: Periodontitis (PD) is influenced by genetic as well as life-style and socio-economic factors. Epidemiological studies show that men are at greater risk of severe forms of PD, suggesting interplay between sex and genetic factors. We aimed to systematically analyze patients with aggressive periodontitis (AgP) for gene-sex interactions. MATERIALS AND METHODS: 329 German AgP cases and 983 controls were genotyped with Affymetrix 500K Arrays and were analyzed by logistic regression analysis. The most significant gene-sex interaction was replicated in an independent sample of 382 German/Austrian AgP cases and 489 controls. RESULTS: Ten single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium (r(2) >0.85) upstream the gene neuropeptide Y (NPY) suggested gene-sex interaction (p<5x10(-5) ). SNP rs198712 showed the strongest association in interaction with sex (p=5.4x10(-6) ) with odds ratios in males and females of 1.63 and 0.69, respectively. In the replication, interaction of sex with rs198712 was verified with p=0.022 (pooled p=4.03x10(-6) ) and similar genetic effects. Analysis of chromatin elements from ENCODE data revealed tissue specific transcription at the associated non-coding region. CONCLUSION: The current study is the first to observe a sexually dimorphic role of alleles at NPY in humans and support previous genome-wide findings of a role of NPY in severe PD.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
Publication type
Article: Journal article
Document type
Scientific Article
Thesis type
Editors
Keywords
Npy ; Interaction ; Periodontitis ; Sex ; Genetic Association
Keywords plus
Language
english
Publication Year
2014
Prepublished in Year
HGF-reported in Year
2014
ISSN (print) / ISBN
0303-6979
e-ISSN
1600-051X
ISBN
Book Volume Title
Conference Title
Conference Date
Conference Location
Proceedings Title
Quellenangaben
Volume: 41,
Issue: 12,
Pages: 1115-1121
Article Number: ,
Supplement: ,
Series
Publisher
Wiley
Publishing Place
Day of Oral Examination
0000-00-00
Advisor
Referee
Examiner
Topic
University
University place
Faculty
Publication date
0000-00-00
Application date
0000-00-00
Patent owner
Further owners
Application country
Patent priority
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-504091-001
Grants
Copyright
Erfassungsdatum
2014-10-09