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Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans.
Nat. Commun. 5:4879 (2014)
Dietary restriction (DR) increases healthspan and longevity in many species, including primates, but it is often accompanied by impaired reproductive function. Whether signals associated with the reproductive system contribute to or are required for DR effects on lifespan has not been established. Here we show that expression of the cytochrome P450 DAF-9/CYP450 and production of the steroid hormone Δ(7)-dafachronic acid (DA) are increased in C. elegans subjected to DR. DA signalling through the non-canonical nuclear hormone receptor NHR-8/NHR and the nutrient-responsive kinase let-363/mTOR is essential for DR-mediated longevity. Steroid signalling also affects germline plasticity in response to nutrient deprivation and this is required to achieve lifespan extension. These data demonstrate that steroid signalling links germline physiology to lifespan when nutrients are limited, and establish a central role for let-363/mTOR in integrating signals derived from nutrients and steroid hormones.
Impact Factor
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Times Cited
Times Cited
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10.742
2.685
50
49
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
C-elegans; Germ-line; Caloric Restriction; Larval Development; Induced Longevity; Extension; Receptor; Pathway; Kinase; Identification
Language
english
Publication Year
2014
HGF-reported in Year
2014
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 5,
Article Number: 4879
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Research Unit BioGeoChemistry and Analytics (BGC)
POF-Topic(s)
30202 - Environmental Health
Research field(s)
Environmental Sciences
PSP Element(s)
G-504800-001
PubMed ID
25209682
WOS ID
WOS:000342983300006
Erfassungsdatum
2014-10-09