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Pastore, F. ; Greif, P.A. ; Schneider, S.* ; Ksienzyk, B.* ; Mellert, G.* ; Zellmeier, E.* ; Braess, J.* ; Sauerland, C.M.* ; Heinecke, A.* ; Krug, U.* ; Berdel, W.E.* ; Buechner, T.* ; Woermann, B.J.* ; Hiddemann, W. ; Spiekermann, K.

The NPM1 mutation type has no impact on survival in cytogenetically normal AML.

PLoS ONE 9:e109759 (2014)
Publ. Version/Full Text DOI PMC
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NPM1 mutations represent frequent genetic alterations in patients with acute myeloid leukemia (AML) associated with a favorable prognosis. Different types of NPM1 mutations have been described. The purpose of our study was to evaluate the relevance of different NPM1 mutation types with regard to clinical outcome. Our analyses were based on 349 NPM1-mutated AML patients treated in the AMLCG99 trial. Complete remission rates, overall survival and relapse-free survival were not significantly different between patients with NPM1 type A or rare type mutations. The NPM1 mutation type does not seem to play a role in risk stratification of cytogenetically normal AML.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2014
HGF-reported in Year 2014
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 9, Issue: 10, Pages: , Article Number: e109759 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-521000-001
PubMed ID 25299584
DOI 10.1371/journal.pone.0109759
WOS ID WOS:000343941200071
Scopus ID 84907835094
Erfassungsdatum 2014-10-11
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