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Open Access Green as soon as Postprint is submitted to ZB.
siRNA liposome-gold nanorod vectors for multispectral optoacoustic tomography theranostics.
Nanoscale 6, 13451-13456 (2014)
Therapeutic applications of gene silencing using siRNA have seen increasing interest over the past decade. The optimization of the delivery and biodistribution of siRNA using liposome-gold nanorod (AuNRs) nanoscale carriers can greatly benefit from adept imaging methods that can visualize the time-resolved delivery performance of such vectors. In this work, we describe the effect of AuNR length incorporated with liposomes and show their complexation with siRNA as a novel gene delivery vehicle. We demonstrate the application of multispectral optoacoustic tomography (MSOT) to longitudinally visualize the localisation of siRNA carrying liposome-AuNR hybrids within tumors. Combination of in vivo MSOT with ex vivo fluorescence cryo-slice imaging offers further insight into the siRNA transport and activity obtained.
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Publication type
Article: Journal article
Document type
Scientific Article
ISSN (print) / ISBN
2040-3364
e-ISSN
2040-3372
Journal
Nanoscale
Quellenangaben
Volume: 6,
Issue: 22,
Pages: 13451-13456
Publisher
Royal Society of Chemistry (RSC)
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)